Author

Mitsugu Shimobayashi

KU LeuvenORCID 0000-0002-6936-0990Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Mitsugu Shimobayashi1 paper · Institute of Human Biology (IHB), Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland;

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1

Frequent Co-Authors

Adrian ListoniD· 1 shared Alexander DumareyiD· 1 shared Alexandre Denadai‐SouzaiD· 1 shared Anne Christin Meyer‐GerspachiD· 1 shared Astrid VerbiestiD· 1 shared Bart Van der SchuereniD· 1 shared Bethan K. DaviesiD· 1 shared Bettina Karin WölnerhansseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

Adrian ListonORCID

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3 papers

Recent·Most cited

Cirrhosis-associated immune dysfunction reflects impaired intestinal CD8ab⁺ intraepithelial lymphocyte compartmentalization

Cansu Akkaya, Matthias van Sligtenhorst, Sadia Shaukat, Elodie Modave, Alexander Dumarey, Gabriel Henrique Caxali, Astrid Verbiest, Lise De Meyere, Stiene Vrancken, Lize Van Meerbeeck, Lukas Van Melkebeke, Nina Dedoncker, Stéphanie Humblet‐Baron, Oliver T. Burton, Adrian Liston, , Alexandre Denadai‐Souza

The paper investigates immune dysfunction in cirrhosis by analyzing CD8ab⁺ intraepithelial lymphocytes and identifies CCL25-CCR9 axis disruption as a key factor.

bioRxiv · Oct 14, 2026 · PreprintImmunology

A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice

Joke Seuntjens, Jente De Gols, Bethan K. Davies, Fien Van Looy, Ingrid Stockmans, Karen Moermans, Geert Carmeliet, Christophe Matthys, Roman Vangoitsenhoven, Bart Van der Schueren, Steve Stegen, Mitsugu Shimobayashi

A dietary intervention after stopping incretin analog therapy restores adipose tissue function and prevents weight regain in diet-induced obese mice.

American Journal of Physiology-Endocrinology and Metabolism · May 28, 2025Peer-reviewedPhysiology

MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism

Carla Elizabeth Cadena del Castillo, Onur Deniz, Femke van Geest, Lore Rosseels, Ingrid Stockmans, Marius R. Robciuc, Sébastien Carpentier, Bettina Karin Wölnerhanssen, Anne Christin Meyer‐Gerspach, Ralph Peterli, Ville Hietakangas, Mitsugu Shimobayashi

This study shows MLX phosphorylation is required for ChREBP-MLX heterotetramer formation on ChoREs, regulating carbohydrate and lipid metabolism.

Science Advances · Mar 12, 2025Peer-reviewedCell Biology