Author

Onur Deniz

University of HelsinkiORCID 0000-0002-9001-9121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Ville HietakangasiD· 4 shared Jaakko MattilaiD· 3 shared Kateryna GaertneriD· 2 shared Krista KokkiiD· 2 shared Tuuli KirkineniD· 2 shared Anne Christin Meyer‐GerspachiD· 1 shared Arto ViitaneniD· 1 shared Atte Hallasaari· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersPhysiology

Ville HietakangasORCID

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Author profile →

5 papers

Recent·Most cited

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

Nicole Lamichane, Petteri Borgman, Terhi Rintakangas, Kateryna Gaertner, Marius Robciuc, Onur Deniz, Tuuli Kirkinen, Cornelia Biehler, Simon Andersson, Jenny Barlund, Oona Kinnunen, Pekka Katajisto, Jaakko Mattila, Ville Hietakangas

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

bioRxiv · Nov 4, 2026 · PreprintPhysiology

Spalt-related is an integrated stress response-activated inhibitor of mTORC1-mediated growth

Onur Deniz, Liu Y, Tuuli Kirkinen, Krista Kokki, Kateryna Gaertner, Pau Clavell-Revelles, Jaakko Mattila, Ville Hietakangas

This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.

The EMBO Journal · Jul 11, 2026Peer-reviewedCell Biology

Nuclear Factor Y controls epithelial growth by regulating mTOR in the Drosophila midgut

Tetiana R. Strutynska, Onur Deniz, Jaakko Mattila

This study shows that NF-Y regulates mTORC1 activity in Drosophila midgut ISC to control epithelial growth under nutrient-rich conditions.

bioRxiv · Feb 2, 2026 · PreprintPhysiology

Metabolic control of enteroendocrine cell fate through a redox state sensor CtBP

Bohdana M. Rovenko, Kari Moisio, Cornélia Biehler, Mykhailo Girych, Atte Hallasaari, Onur Deniz, Sarah Bluhm, Arto Viitanen, Krista Kokki, Gaia Fabris, Yi Yang, Valentin Cracan, Irene Miguel‐Aliaga, Ville Hietakangas

This study identifies CtBP as a redox state sensor that controls enteroendocrine cell fate in Drosophila by integrating metabolic signals with transcriptional regulation.

bioRxiv · Jun 30, 2025 · PreprintPhysiology

MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism

Carla Elizabeth Cadena del Castillo, Onur Deniz, Femke van Geest, Lore Rosseels, Ingrid Stockmans, Marius R. Robciuc, Sébastien Carpentier, Bettina Karin Wölnerhanssen, Anne Christin Meyer‐Gerspach, Ralph Peterli, Ville Hietakangas, Mitsugu Shimobayashi

This study shows MLX phosphorylation is required for ChREBP-MLX heterotetramer formation on ChoREs, regulating carbohydrate and lipid metabolism.

Science Advances · Mar 12, 2025Peer-reviewedCell Biology