Author

Michael Lape

Cincinnati Children's Hospital Medical CenterORCID 0000-0002-6941-9593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:GWAS / association mapping· 1 Assay:Hi-C· 1

Frequent Co-Authors

Leah Claire KottyaniD· 2 shared Adam Samuel Gordon· 1 shared Albert Frank Magnusen· 1 shared Bahram Namjou‐Khales· 1 shared Bo ZhaoiD· 1 shared Carmy R. ForneyiD· 1 shared Chunhua WengiD· 1 shared Daniel J. SchaidiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Leah Claire KottyanORCID

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2 papers

Recent·Most cited

Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record

Elisabeth A. Rosenthal, Wei‐Qi Wei, Yuan Luo, Bahram Namjou‐Khales, Daniel J. Schaid, Edward D. Esplin, Michael Lape, Leah Claire Kottyan, Jennifer A. Pacheco, Chunhua Weng, Adam Samuel Gordon, Iftikhar J. Kullo, David R. Crosslin, William M. Grady, Li Hsu, , Gail Pairitz Jarvik

The paper uses a polygenic risk score for colorectal cancer in a PheWAS to find genetic correlations with other phenotypes from electronic health records.

medRxiv · Feb 26, 2025 · PreprintGenetic & Genomic Medicine

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci

Ted Hong, Sreeja Parameswaran, Omer A. Donmez, Daniel Miller, Carmy R. Forney, Michael Lape, Mariana Saint Just Ribeiro, Jun Liang, Lee Edsall, Albert Frank Magnusen, William E. Miller, Iouri Chepelev, John B. Harley, Bo Zhao, Leah Claire Kottyan, Matthew T. Weirauch

This study shows EBNA2 alters chromatin structure and gene expression at autoimmune risk loci, linking viral infection to genetic risk mechanisms in autoimmune diseases.

Genome Research · Dec 1, 2021Peer-reviewedGenomics