William M. Grady

Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression

The paper uses spatial multi-omics and single-cell transcriptomics to identify senescence-associated programs in colon adenoma to cancer progression, finding GDF15 mediates senescence-stemness coupling and immune exclusion.

3D pathology-guided microdissection

This paper introduces a 3D microdissection method combining CNC milling and light-sheet microscopy to study tumor evolution in complex 3D structures.

Assessing the effects of a 3D pathology tissue-processing workflow on downstream molecular analyses

This study evaluates the impact of a 3D pathology workflow on DNA, RNA, and protein integrity, showing minimal effect on amplifiability and transcriptomic profiles.

Translating Histopathology Foundation Model Embeddings into Cellular and Molecular Features for Clinical Studies

STpath translates histopathology image embeddings into cell-type composition and gene expression estimates for clinical applications.

Deep-learning triage of 3D pathology datasets for comprehensive and efficient pathologist assessments

CARP3D uses deep learning to prioritize high-risk 2D sections in 3D pathology data, improving disease detection while reducing pathologist workload.

Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record

The paper uses a polygenic risk score for colorectal cancer in a PheWAS to find genetic correlations with other phenotypes from electronic health records.

Genetic architectures of proximal and distal colorectal cancer are partly distinct

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.