Epigenetic control of CD8+ T cell tissue homing and tissue resident memory T cell precursors by the histone methyltransferase SUV39H1
Guadalupe Suárez, Sandrine Heurtebise-Chrétien, Pierre‐Emmanuel Bonté, Héloïse Beuchet, Jaime R. Fuentealba, Christel Goudot, Olivier J Lantz, Sebastián Amigorena
This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.
bioRxiv · May 13, 2024 · PreprintImmunology