Jaime R. Fuentealba

The paper demonstrates that TCR-T cells targeting neogene-encoded antigens can specifically kill Ewing sarcoma cells in vitro and in vivo.

This study investigates how Neuropilin-1 (NRP-1) on solid tumors affects CAR T cell function, finding that NRP-1 transfer via trogocytosis may impair CAR T cell activity.

The paper introduces DivisionCounter, a method to count large cell divisions in vivo, showing leukemia tumor division rates are independent of microenvironment and CAR-T treatment.

This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.