Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK
Dong-Kyo Lee, Xian Jin, Poo-Reum Choi, Ying Jun Cui, Xiangguo Che, Sihoon Lee, Keun Hur, Hyun‐Ju Kim, Je‐Yong Choi
This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.
Experimental & Molecular Medicine · Feb 2, 2025Peer-reviewedCell Biology