Andrew A. Bridges

Genome-scale label-free imaging reveals cellular physiology encoded in bacterial collective architecture

The paper introduces PULLI, a computer vision platform that extracts phenotypes from bacterial growth timelapses, revealing genotype-phenotype relationships in Vibrio cholerae mutants.

Label-free microscopy enables high-throughput identification of genes controlling biofilm development

This study introduces LFAB, a label-free microscopy method for high-throughput biofilm analysis, and identifies key genes regulating biofilm formation in Streptococcus pneumoniae.

A branching cell-fate decision in biofilm dispersal enables long-term surface persistence

The paper shows that during biofilm dispersal, a subpopulation of cells forms a resilient post-dispersal biofilm community that can re-populate the niche and resist antibiotics and bacteriophages.

A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system

This study identifies DbfQ as a periplasmic protein that modulates the DbfRS two-component system in Vibrio cholerae, affecting biofilm dispersal and transcriptional responses to environmental stress.

Biofilm dispersal patterns revealed using far-red fluorogenic probes

This study uses far-red fluorogenic probes to reveal single-cell dispersal patterns in Vibrio cholerae biofilms, showing that dispersal starts at the periphery and 25% of cells never disperse.

Deep Video Analysis for Bacteria Genotype Prediction

This paper uses video analysis to predict bacterial genotypes from spatiotemporal growth patterns, showing that low-resolution microscopy videos can classify genetic modifications in Vibrio cholerae.