Grant A Fox

Tau is an m6A-associated RNA binding protein that causes RNA dysregulation in disease

The paper identifies tau as an m6A-associated RNA binding protein that causes RNA dysregulation in MAPT coding-variant patients and V337M iNeurons.

Systematic contextual biases in SegmentNT potentially relevant to other nucleotide transformer models

The paper identifies contextual biases in the SegmentNT model, showing how input sequence length and nucleotide position affect predictions and suggests ways to mitigate these biases.

Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics

The paper introduces CTACIT to fine-map neuropsychiatric regulatory variants by integrating conservation scores with cell type-specific open chromatin data across species.

An in vivo massively parallel platform for deciphering tissue-specific regulatory function

The paper introduces WhAMPRA, an in vivo MPRA platform in mice, to assess tissue-specific regulatory functions of genetic variants and enhancers.

Using deep long-read RNAseq in Alzheimer's disease brain to assess medical relevance of RNA isoform diversity

The paper uses long-read RNAseq to identify new RNA isoforms in Alzheimer's disease brain tissue and demonstrates their medical relevance.

Machine learning sequence prioritization for cell type-specific enhancer design

The paper introduces SNAIL, a virus-based method using machine learning to design cell type-specific enhancer probes for targeted nuclear isolation and characterization.