Dan Lü

Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing

This study identifies a DNA binding region in MORC2 that is essential for gene silencing and shows that phosphorylation affects its DNA affinity and nuclear localization.

SubCell: Proteome-aware vision foundation models for microscopy capture single-cell biology

SubCell is a deep learning model for fluorescence microscopy that captures cellular morphology and protein organization, outperforming existing methods and enabling a multimodal approach to gene function.

MSModDetector: A Tool for Detecting Mass Shifts and Post-Translational Modifications in Individual Ion Mass Spectrometry Data

MSModDetector identifies PTM patterns in individual ion mass spectrometry data by detecting mass shifts and using linear programming to infer modifications.

Analysing protein post-translational modform regions by linear programming

The paper uses linear programming to estimate modform distributions of proteins with multiple post-translational modifications, showing that combining bottom-up and top-down MS data reduces average modform range.

A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified forms

The paper uses a multi-modal proteomics approach to analyze PTMs of p53, revealing many modification sites but few distinct modified forms.