Luca Fornelli

This study identifies acetylation sites on yeast Ydj1 that affect its interactions with chaperones and client proteins, impacting proteostasis and translational fidelity.

This paper uses cross-linking mass spectrometry to characterize Hsp70 interactions in budding yeast, revealing self-association, multi-point client interactions, and novel PTMs critical for client function.

The paper analyzes SARS-CoV-2 spike glycoprotein sequences to show that indels are common and increasing, with implications for viral evolution and vaccine efficacy.

The paper uses a multi-modal proteomics approach to analyze PTMs of p53, revealing many modification sites but few distinct modified forms.