Caroline J. DeHart

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

Analysing protein post-translational modform regions by linear programming

The paper uses linear programming to estimate modform distributions of proteins with multiple post-translational modifications, showing that combining bottom-up and top-down MS data reduces average modform range.

A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified forms

The paper uses a multi-modal proteomics approach to analyze PTMs of p53, revealing many modification sites but few distinct modified forms.