Ashwini Jambhekar

This study shows DNA damage checkpoints balance a tradeoff between reducing arrest failure in diploid and polyploid cells, with optimal checkpoint strengths being suboptimal for each failure type.

The paper investigates how p21 transcription variability arises through an incoherent feedforward loop involving p53 and MDM2, showing it enables rapid p21 induction and treatment-tolerant cell states.

MSModDetector identifies PTM patterns in individual ion mass spectrometry data by detecting mass shifts and using linear programming to infer modifications.

The paper shows that a bHLH circuit enables neural stem cells to choose astrocytic fate by integrating BMP and LIF signals and suppressing alternative fates.

The paper investigates how varying ERK activity levels influence proliferation in cells undergoing oncogene-induced senescence, finding intermediate ERK activity promotes maximal proliferation.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.