Author

David A. Mankoff

University of PennsylvaniaORCID 0000-0002-6971-5413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Amulya SreekumariD· 1 shared Anupma NayakiD· 1 shared Austin Pantel· 1 shared Charles‐Antoine AssenmacheriD· 1 shared Chris Hensley· 1 shared Christopher J. SterneriD· 1 shared Dhruv K. PantiD· 1 shared Elizabeth J. LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Amulya SreekumarORCID

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2 papers

Recent·Most cited

L-5--glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine Metabolism

Raheema A. Damani, Chris Hensley, Hoon Choi, Hsiaoju Lee, Rong Zhou, Austin Pantel, David A. Mankoff, Elizabeth J. Li

This study uses [11C]glutamine PET to analyze glutamine metabolism in breast cancer mouse models, revealing subtype-specific metabolic differences and the impact of GLS1 inhibition.

bioRxiv · Jul 3, 2026 · PreprintBioengineering

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan, Dhruv K. Pant, Sarah Acolatse, Hamza Turkistani, George K. Belka, Anupma Nayak, Sean Carlin, Charles‐Antoine Assenmacher, Mark A. Sellmyer, David A. Mankoff, Lewis A. Chodosh

This study identifies SOX5 as a key factor enabling residual breast cancer cells to maintain dormancy through endochondral ossification, improving recurrence-free survival.

Cancer Discovery · Dec 10, 2025Peer-reviewedCancer Biology