Anupma Nayak

Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers

This study compares genomic and immunologic features of germline TP53-driven breast cancers to sporadic breast cancers, finding distinct patterns of genomic instability and immune infiltration.

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

This study identifies SOX5 as a key factor enabling residual breast cancer cells to maintain dormancy through endochondral ossification, improving recurrence-free survival.

Designing smart spatial omics experiments with S2Omics

S2Omics automatically selects regions of interest from histology images to maximize molecular information content in spatial omics experiments, improving reproducibility and downstream biological discovery.

Genomic profiling of young-onset gBRCA1/2 breast cancer reveals distinct genomic landscapes and therapeutic implications for PARP and CDK4/6 inhibitor selection

This study compares genomic features of gBRCA1 and gBRCA2 breast cancers, finding distinct mutational patterns and therapeutic implications for PARP and CDK4/6 inhibitors.