Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B
Donghoon Chung, Yuka Otsuka, Eunjung Kim, Sultan Ullah, Nicole M. Kennedy, Khac Huy Ngo, Jinjoo Kang, Reece Tomlinson, Brian S. Alejandro, Koji Barnaby, Jeffrey Miller, Justin Shumate, CG Teo, Yaw Bia Tan, Che Shin Chew, , Thomas D. Bannister
This paper identifies potent benzamide compounds against Zika virus by targeting NS4B, showing superior potency and novel resistance mutation patterns compared to existing treatments.
PLoS Pathogens · Apr 3, 2026Peer-reviewedMicrobiology