Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors
Joanna K. Lempiäinen, Kirill Miachin, Xingyu Liu, Kuangying Yang, Cynthia Horth, Eric Bareke, Maya Grinwald, Wesley N. Saintilnord, Ting Wang, Jacek Majewski, Angela C. Hirbe, Benjamin A. Garcia
This study identifies IGF2 as a therapeutic target in PRC2-deficient MPNSTs by linking PRC2 loss to chromatin remodeling and activation of the IGF2-IGF2BP axis.
bioRxiv · Nov 5, 2025 · PreprintCancer Biology