Author

Joanna K. Lempiäinen

Washington University in St. LouisORCID 0000-0001-6100-5815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrew Q. RashoffiD· 1 shared Angela C. HirbeiD· 1 shared Audrey BaguetteiD· 1 shared Benjamin A. GarciaiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Caterina RussoiD· 1 shared Claudia L. KleinmaniD· 1 shared Cynthia HorthiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Andrew Q. RashoffORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 5, 2025

Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors

Joanna K. Lempiäinen, Kirill Miachin, Xingyu Liu…·Benjamin A. Garcia

This study identifies IGF2 as a therapeutic target in PRC2-deficient MPNSTs by linking PRC2 loss to chromatin remodeling and activation of the IGF2-IGF2BP axis.

1 citation

humanproteomics

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Molecular BiologybioRxivPreprintJul 18, 2025

SUZ12-Nucleic Acid Interactions Constrain PRC2 Activity to Maintain Targeted Gene Silencing Essential to Diffuse Midline Glioma

Tyler J. Reich, Paul A. Clark, Audrey Baguette…·Peter W. Lewis

The paper identifies SUZ12's nucleic acid-binding domain as critical for regulating PRC2 activity in H3 K27M gliomas, showing how it constrains enzymatic function and maintains targeted gene silencing.

1 citation

humanChIP-seq

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