The paper creates a detailed computational model of rat somatosensory cortex anatomy, including 4.2 million neurons and 14.2 billion synapses, and identifies limitations in connectivity prediction from morphology.

eLife · Jan 20, 2026Peer-reviewedNeuroscience

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

James B. Isbister, András Ecker, Christoph Pokorny, Sirio Bolaños‐Puchet, Daniela Egas Santander, Alexis Arnaudon, Omar Awile, Natalí Barros-Zulaica, Jorge Blanco Alonso, Elvis Boci, Giuseppe Chindemi, Jean-Denis Courcol, Tanguy Damart, Thomas Delemontex, Alexander Dietz, , Michael Reimann

The paper presents a large-scale biophysically detailed model of somatosensory cortex to simulate and validate cortical dynamics and experimental results.

eLife · Jan 20, 2026Peer-reviewedNeuroscience

A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations

Christoph Pokorny, Omar Awile, James B. Isbister, Kerem Kurban, Matthias Wolf, Michael Reimann

The paper introduces a framework for manipulating neuronal connectomes in simulations to study structure-function relationships, finding causal shifts in neuronal activity from connectivity changes.

Network Neuroscience · Dec 2, 2024Peer-reviewedNeuroscience

Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitry

Elisabetta Iavarone, Jane Simko, Ying Shi, Marine Bertschy, María García‐Amado, Polina Litvak, Anna-Kristin Kaufmann, Christian O’Reilly, Oren Amsalem, Marwan Abdellah, Grigori Chevtchenko, Benoît Coste, Jean-Denis Courcol, András Ecker, Cyrille Favreau, , Sean Hill

The paper develops a computational model of mouse thalamoreticular microcircuitry to study sensory enhancement and sleep spindle properties, revealing mechanisms of network-level activity across brain states.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience