Jane Simko

Local thalamic interneurons drive spindle termination and enable sleep-dependent learning

This study identifies local thalamic interneurons as critical for regulating spindles and sleep-dependent learning by modulating thalamocortical activity.

Functional architecture of intracellular oscillations in hippocampal dendrites

The paper uses two-photon imaging and electrophysiological recordings to study dendritic membrane potential dynamics in mouse hippocampal pyramidal cells during behavior, revealing spatial and temporal patterns of electrical signaling.

Behavioral control through the direct, focal silencing of neuronal activity

This paper introduces a method to reversibly control neuronal activity using a light-activated saxitoxin inhibitor, demonstrating its effectiveness in altering behavior in zebrafish without genetic modification.

Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitry

The paper develops a computational model of mouse thalamoreticular microcircuitry to study sensory enhancement and sleep spindle properties, revealing mechanisms of network-level activity across brain states.