Author

Matthew D. Lauver

Pennsylvania State UniversityORCID 0000-0002-7001-9730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aron E. LukacheriD· 2 shared Ge Jin· 2 shared Kalynn M AlexanderiD· 2 shared Katelyn Nicole AyersiD· 2 shared Alyssa OchettoiD· 1 shared Anirban PauliD· 1 shared Arrienne B. ButiciD· 1 shared ChaeMin KimiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Aron E. LukacherORCID

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2 papers

Recent·Most cited

ImmunologyDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedAug 17, 2026

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

Arrienne B. Butic, Elia Afanasiev, Samantha A. Spencer…·Aron E. Lukacher

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

DOI 10.1038/s41467-026-76762-3

mousescRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 22, 2024

The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants

Katelyn Nicole Ayers, Matthew D. Lauver, Kalynn M Alexander…·Aron E. Lukacher

Pre-existing and acquired CD4 T cell deficiency facilitates outgrowth of Ab-escape viral variants during persistent infection.

3 citations

mouseexperimental assay

𝕏 PostBluesky