Author

Joseph A. Politch

Boston UniversityORCID 0000-0002-7022-0135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Deborah Jean AndersoniD· 4 shared Jai G. MaratheiD· 3 shared Catherine E. CostelloiD· 2 shared Kevin J. WhaleyiD· 2 shared Purna Shah· 2 shared Sarah DohadwalaiD· 2 shared Chaoshuang XiaiD· 1 shared Emilie MausseriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersImmunology

Deborah Jean AndersonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Human Contraceptive Antibody Targets A Semenogelin Galectin-3 N-Linked Glycan Complex on the Sperm Surface

Sarah Dohadwala, Chaoshuang Xia, Shane Finn, Purna Shah, Shang‐Chuen Wu, Hau Ming Jan, Joseph A. Politch, Kevin J. Whaley, Sean R. Stowell, Stacy Alyse Malaker, Catherine E. Costello, Deborah Jean Anderson

This paper identifies the HCA antibody's target as a semenogelin-galectin-3 complex on the sperm surface, rather than CD52, through affinity purification and glycan analysis.

bioRxiv · Oct 14, 2026 · PreprintImmunology

Complement protein concentrations and activity in human cervical mucus

Jai G. Marathe, Emilie Mausser, Joseph A. Politch, Maria Tjilos, Deborah Jean Anderson

This study quantifies complement protein levels in cervical mucus across the menstrual cycle, finding significant variations in concentrations and functional activity compared to serum.

bioRxiv · Jul 22, 2026 · PreprintImmunology

Sialidases derived from Gardnerella vaginalis and Prevotella Timonensis remodel the sperm glycocalyx and impair sperm function

Sarah Dohadwala, Purna Shah, Maura K Farrell, Joseph A. Politch, Jai G. Marathe, Catherine E. Costello, Deborah Jean Anderson

This study shows that sialidases from BV-associated bacteria damage the sperm glycocalyx, increasing susceptibility to agglutination and impairing cervical mucus transit.

Glycobiology · Oct 30, 2025Peer-reviewedImmunology

Revolutionizing male contraception: Personal lubricants as a novel way to deliver the Human Contraception Antibody

James Doud, Matthew T. Geib, Joseph A. Politch, Kevin J. Whaley, Deborah Jean Anderson, Jai G. Marathe

This study shows that personal lubricants can deliver the Human Contraception Antibody (HCA) effectively, with silicone-based formulations showing higher delivery efficiency.

bioRxiv · Aug 14, 2025 · PreprintBioengineering