The Human Contraceptive Antibody Targets A Semenogelin Galectin-3 N-Linked Glycan Complex on the Sperm Surface
Sarah Dohadwala, Chaoshuang Xia, Shane Finn, Purna Shah, Shang‐Chuen Wu, Hau Ming Jan, Joseph A. Politch, Kevin J. Whaley, Sean R. Stowell, Stacy Alyse Malaker, Catherine E. Costello, Deborah Jean Anderson
This paper identifies the HCA antibody's target as a semenogelin-galectin-3 complex on the sperm surface, rather than CD52, through affinity purification and glycan analysis.
bioRxiv · Oct 14, 2026 · PreprintImmunology