R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements
David Ellis, Félix Reyes Martín, Maria Rodríguez‐López, Cristina Cotobal, Xi-Ming Sun, Quentin Saintain, Daniel Charlton Jeffares, Samuel Marguerat, Víctor A. Tallada, Jürg Bähler
The paper identifies age-related genome rearrangements in non-dividing fission yeast cells, linking them to R-loops and regulatory changes, and finds similar patterns in human brain cells.
PLoS Genetics · Aug 31, 2021Peer-reviewedGenomics