Xi-Ming Sun

This study identifies a lncRNA, aal1, that extends lifespan in fission yeast by reducing ribosome content and protein translation, with similar effects observed in Drosophila.

The paper identifies age-related genome rearrangements in non-dividing fission yeast cells, linking them to R-loops and regulatory changes, and finds similar patterns in human brain cells.

The paper investigates how RNA Polymerase II initiation rates scale with cell size in fission yeast, showing that RNAPII is a limiting factor for transcriptional scaling.

The paper uses scRNA-seq and imaging to study gene expression heterogeneity in fission yeast under different environmental conditions, revealing how gene expression varies during growth and stress responses.

This study shows condensin affects RNA levels by causing chromosome missegregation, not by directly regulating transcription.