Jürg Bähler

The paper compares gene function and expression in dormant cells of yeast spores and killifish diapause embryos, finding conserved transcriptomic and proteomic changes across species.

The paper identifies genetic and environmental factors influencing multicellular-like phenotypes in fission yeast through experimental and genomic analyses.

This study identifies a lncRNA, aal1, that extends lifespan in fission yeast by reducing ribosome content and protein translation, with similar effects observed in Drosophila.

The paper shows that DNA binding is essential for most functions of CSL proteins in fission yeast, including cell cycle, lipid metabolism, and genome integrity.

The paper uses phenomics and machine learning to predict protein functions in fission yeast, identifying novel roles and validating predictions through experimental validation.

The paper shows that fatty-acid synthesis defects in fission yeast lead to chromatin hyperacetylation, stress-response gene activation, and oxidative stress resistance.

The paper identifies a central state transition in yeast molecular networks linked to PKA and TOR signaling, showing how genetic variants can cause global or local molecular changes affecting multiple cellular traits.

The paper identifies pervasive mRNA uridylation in fission yeast using RNA-seq data and shows both Cid1 and Cid16 contribute to this process, with no major physiological phenotype observed.

The paper describes PomBase, a database for fission yeast, and highlights its features and contributions to the model organism database community.

The paper functionally profiles long intergenic non-coding RNAs (lincRNAs) in fission yeast by analyzing mutant phenotypes across various conditions.

The paper identifies age-related genome rearrangements in non-dividing fission yeast cells, linking them to R-loops and regulatory changes, and finds similar patterns in human brain cells.

This study introduces improved methods for studying chronological lifespan in fission yeast, identifying new ageing-associated genes with potential relevance to human ageing.

The paper shows that C. elegans hermaphrodites undergo reproductive death after reproduction, which is suppressed by germline removal and linked to lifespan extension.

This study shows that C. elegans mothers transfer yolk to offspring via lactation, a process promoted by insulin/IGF-1 signalling, leading to reproductive death.

The paper shows that mitochondrial respiration in fission yeast supports rapid proliferation during fermentation by supplying Krebs-cycle derived amino acids.

Pyphe automates and improves analysis of microbial fitness screens by processing colony size, viability, and growth curve data from low-cost imaging.

The paper identifies a natural variant in fission yeast Pyk1 that reduces glycolytic flux, increases respiration, and enhances oxidative-stress resistance but decreases growth.

This study characterizes the temporal transcriptome and promoter architecture of African Swine Fever Virus during early and late infection, revealing distinct promoter motifs and transcription termination mechanisms.

The paper uses transposon mutagenesis and a hidden Markov model to identify functional elements in the fission yeast genome, finding that 90% of the genome has fitness consequences.

The paper uses scRNA-seq and imaging to study gene expression heterogeneity in fission yeast under different environmental conditions, revealing how gene expression varies during growth and stress responses.

The paper identifies conserved but unstudied proteins in yeast and human, highlighting their potential importance and proposing strategies to better characterize them.

The paper shows that disrupting dNTP homeostasis is synthetically lethal with CDK-induced replication stress in fission yeast, leading to genome instability and cell death.

This study identifies ETS transcription factors as conserved regulators of longevity across species, showing their roles in modulating lifespan through gene expression programs.

The paper identifies 5775 novel lncRNAs in fission yeast and characterizes their regulation by RNA-processing pathways.

The paper identifies natural genetic variants associated with longevity in fission yeast by analyzing segregant pools and genome sequencing during aging.

The paper investigates the interaction between Cdk9, H2Bub1, and the Clr6-CII HDAC complex in regulating antisense and sense transcription in fission yeast.

The paper investigates how structural variations in yeast genomes affect gene expression and quantitative traits, finding that copy number variants significantly influence phenotypes and reproductive isolation.

The paper introduces proportionality as an alternative to correlation for analyzing relative compositional data, demonstrating its validity using yeast gene expression data.