Silvia Budday

Mechanochemical synchronization of force oscillations in connective tissue models

This study shows that multicellular systems coordinate force generation and invasive migration through oscillatory mechanochemical feedback in 3D matrices.

Tuning the mechanical properties of polymer-based surrogate materials for articular cartilage and vocal fold repair

This study develops synthetic surrogate materials for articular cartilage and vocal folds by tuning their mechanical properties to mimic native tissues.

Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness

This study shows that the stiffness ratio between spinal cord gray and white matter changes with indentation bead size, depending on the anatomical plane.

In silico model of axonal pathfinding during spinal cord regeneration in zebrafish larvae

The paper develops an agent-based model to simulate axonal growth during zebrafish spinal cord regeneration and shows it aligns with experimental imaging data.

The Mechanical Fingerprint of Hippocampal Sclerosis Linking Neuronal Cell Loss and Gliosis to Tissue Stiffness

This study links neuronal cell loss and gliosis in hippocampal sclerosis to tissue stiffness using mechanical testing and deep learning analysis of histopathology.

Towards patient-specific biomechanical human brain models

This paper develops a method to estimate patient-specific brain mechanical properties from DTI data, showing that voxel-resolved stiffness distributions improve simulation accuracy compared to region-based approaches.

Fractional Anisotropy as a Surrogate Marker of Brain Mechanics

This study shows fractional anisotropy from MRI correlates with brain tissue stiffness, suggesting it can be used as a non-invasive marker for mechanical properties.

Mechanical impact on neural stem cell lineage decisions in human brain organoids

This study shows that mechanical forces influence neural stem cell lineage decisions in human brain organoids through changes in molecular programs and cellular metabolism.

Integration of customizable 3D printed mixing printheads for controlled and tuneable material and stiffness gradient fabrication with high cell viability in extrusion-based bioprinting

This paper introduces a 3D printed mixing printhead for extrusion-based bioprinting that enables controlled material and stiffness gradients with high cell viability.

Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

This paper develops a physics-based model to explore how the outer subventricular zone influences cortical folding by integrating cellular processes with organ-scale mechanics.