Lucas Hoffmann

The Mechanical Fingerprint of Hippocampal Sclerosis Linking Neuronal Cell Loss and Gliosis to Tissue Stiffness

This study links neuronal cell loss and gliosis in hippocampal sclerosis to tissue stiffness using mechanical testing and deep learning analysis of histopathology.

Neuronal precursor cell persistence in Ganglioglioma is associated with ECM remodeling and immune cell infiltration

This study uses spatial transcriptomics to identify transcriptional programs in gangliogliomas that link ECM remodeling, immune infiltration, and persistent neuronal precursor-like states to tumor biology.

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions

This study identifies somatic and germline genetic variants in 474 epileptogenic brain lesions, revealing associations with specific epilepsy subtypes and informing clinical genetic screening.