Ching‐Yan Chloé Yeung

The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.

The paper examines differences in mononuclear cells and myonuclei at human myofibre tips, finding more mononuclear cells and COL22A1-expressing nuclei in type II fibres compared to type I.

The paper uses single nucleus RNA-seq to identify distinct myonuclei profiles at the human myotendinous junction, revealing gene expression patterns and subclusters associated with specific proteins and fibre types.