Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
Ask Møbjerg, Danielle Steffen, Peter Schjerling, Jens Rithamer Jakobsen, Anja Jokipii‐Utzon, Mykhailo Y. Batiuk, Konstantin V. Khodosevich, Michael Rindom Krogsgaard, Valerio Izzi, Abigail Louise Mackey, Michael Kjær, Ching‐Yan Chloé Yeung
The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.
American Journal of Physiology-Cell Physiology · Oct 21, 2025Peer-reviewedCell Biology