Michael Kjær

Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wasting

This study shows that Rac1 deficiency in muscle reduces mitochondrial function and fatty acid metabolism, leading to muscle wasting and highlights potential therapeutic targets for age-related muscle decline.

Heavy Resistance Exercise Training in Older Men: A Responder and Inter-individual Variability Analysis

Sixteen weeks of heavy resistance exercise in older men produces true inter-individual variability, yet multi-outcome classification shows 82% respond robustly or excellently and only 5% respond poorly.

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.

Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres

The paper examines differences in mononuclear cells and myonuclei at human myofibre tips, finding more mononuclear cells and COL22A1-expressing nuclei in type II fibres compared to type I.

Muscle Fibroblasts and Stem Cells Stimulate Motor Neurons in An Age and Exercise-Dependent Manner

The paper shows that human muscle fibroblasts and stem cells stimulate motor neuron growth and viability, with effects enhanced by exercise and mitigated by age.

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

Distinct myofibre domains of the human myotendinous junction revealed by single nucleus RNA-seq

The paper uses single nucleus RNA-seq to identify distinct myonuclei profiles at the human myotendinous junction, revealing gene expression patterns and subclusters associated with specific proteins and fibre types.