Masahiko Ajiro

This study introduces TISCA2 and IncepTIS to map and predict stress-responsive translation initiation sites, revealing tissue-specific patterns and enabling engineered mRNA 5' leaders.

The paper identifies NECTIN4 as a subtype-dependent determinant of tumor state and antitumor immunity in bladder cancer, linking its expression to response to enfortumab vedotin and checkpoint inhibitors.

This paper introduces SCALE-CLIP, a method to generate comparable RBP binding maps, and defines a positional and combinatorial regulatory code for alternative splicing.

This study shows Zika virus reprograms host tRNA modifications to favor AA-ending codons, enhancing viral protein translation and replication.

This study shows SRSF3 is oncogenic in breast cancer and tumor-suppressive in liver cancer through context-dependent gene regulation.

PDIVAS identifies pathogenic deep-intronic variants causing aberrant splicing with high sensitivity using an ensemble machine-learning model.

The paper identifies a splicing modifier that switches OAS1 isoforms, enhancing resistance to SARS-CoV-2 infection in human lung cells.