Alexei V. Lobanov

CRISPR-Based Gene Dependency Screens reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

This study identifies TAZ deficiency as synthetically lethal with BRAF inhibitors in anaplastic thyroid cancer, revealing a mechanism of resistance and a potential therapeutic target.

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis

Imaging of mitochondria and lipid droplets (LDs) across mouse liver lobules shows fasting, not Western diet, expands mitochondria-LD contacts; PLIN5 phosphomutants tune contacts and lipid storage.

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

SRSF3 is oncogenic in breast but tumor-suppressive in liver by differential regulation of gene expression

This study shows SRSF3 is oncogenic in breast cancer and tumor-suppressive in liver cancer through context-dependent gene regulation.

H3K27 Acetylated Nucleosomes Facilitate HMGN Protein Localization at Regulatory Sites to Modulate The Interaction of Transcription Factors with Chromatin

The paper shows HMGN proteins bind to H3K27ac nucleosomes at regulatory sites, modulating transcription factor-chromatin interactions and gene expression.

Iterative Epigenomic Analyses in the Same Single Cell

The paper introduces a method to reanalyze the same single cell for multiple epigenetic marks, enabling reliable signal identification and pathway prediction in K562 cells.