Joana Ferreira da Silva

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

This study shows that removing mismatch repair factors increases prime editing efficiency across multiple cell lines and edits.

BioProfiling.jl provides a Julia package for morphological profiling of high-content imaging data, enabling analysis of cell state changes and integration with molecular target networks.

The paper identifies kinase-specific vulnerabilities and resistances in response to DNA damaging agents using kinase-deficient cell lines and validates gene-drug interactions.