Joanna I. Loizou

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

This study profiles mutations in MMR-deficient human cells and identifies new mutational signatures linked to MMR deficiency and cancer development.

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.

This study shows that removing mismatch repair factors increases prime editing efficiency across multiple cell lines and edits.

BioProfiling.jl provides a Julia package for morphological profiling of high-content imaging data, enabling analysis of cell state changes and integration with molecular target networks.

The paper identifies kinase-specific vulnerabilities and resistances in response to DNA damaging agents using kinase-deficient cell lines and validates gene-drug interactions.