Peter Ian Croucher

ENTRAIN integrates trajectory inference with gene regulatory networks to identify environmental signals driving cell fate by co-localizing receptor-ligand interactions in spatial data.

The paper identifies genes involved in human bone disease by analyzing transcriptomic changes during zebrafish scale regeneration.

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

The paper identifies 14 genes involved in osteoarthritis using mutant mice and validates their role through functional studies and genome editing.

A rare SMAD9 mutation is linked to high bone mass, suggesting the BMP pathway as a potential osteoanabolic target.

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.