Tri Giang Phan

Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer

This paper shows that pulsed narmafotinib priming improves chemotherapy response in pancreatic cancer by reducing fibrosis and enhancing treatment efficacy.

Defocused reflectance imaging for low numerical aperture, large field of view quantitative live cell imaging studies

This paper demonstrates that controlled defocusing in low numerical aperture microscopes improves automated cell segmentation and tracking for high-throughput live-cell imaging.

Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions

This paper introduces RO-iSCAT, a technique that enables real-time, label-free tracking of membrane protrusions with high axial resolution and minimal phototoxicity.

ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor-ligand interactions that specify cell fate

ENTRAIN integrates trajectory inference with gene regulatory networks to identify environmental signals driving cell fate by co-localizing receptor-ligand interactions in spatial data.

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease

The paper challenges a claim that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 by showing that UMAP embeddings may not reflect direct lineage relationships.

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

This paper introduces RAGE-seq, a method combining long-read and short-read sequencing to analyze lymphocyte clonal and transcriptional features in breast cancer tissues.