Author

Davide S. K. Komla-Ebri

Imperial College LondonORCID 0000-0002-8381-5381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Christopher J. LelliottiD· 3 shared David J. AdamsiD· 3 shared Elena J. GhirardelloiD· 3 shared Graham Richard WilliamsiD· 3 shared J. H. Duncan BassettiD· 3 shared John G. LoganiD· 3 shared Natalie C. ButterfieldiD· 3 shared Peter Ian CroucheriD· 3 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Christopher J. LelliottORCID

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3 papers

Recent·Most cited

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease

Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, C. Marcelo Sergio, Michael R.G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide S. K. Komla-Ebri, Ryan Chau Chia Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, , Peter Ian Croucher

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

Nature Communications · May 5, 2021Peer-reviewedSystems Biology

Accelerating functional gene discovery in osteoarthritis

Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah F. Dewhurst, Davide S. K. Komla-Ebri, Naila S. Mannan, Anne‐Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena J. Ghirardello, Lorraine Southam, Scott E. Youlten, Jeremy Mark Wilkinson, Elizabeth A. McAninch, , J. H. Duncan Bassett

The paper identifies 14 genes involved in osteoarthritis using mutant mice and validates their role through functional studies and genome editing.

Nature Communications · Jan 20, 2021Peer-reviewedGenetics

An Atlas of Human and Murine Genetic Influences on Osteoporosis

John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan Chau Chia Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian M.W. Quinn, Loan Nguyen‐Yamamoto, Aimée-Lee Luco, Jinchu Vijay, , John Brent Richards

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.

Nature Genetics · Dec 17, 2018Peer-reviewedGenomics