Jacob L. Berrigan

This study identifies phosphatidylserine receptors as critical for CCHFV infection and shows that targeting these receptors can protect against viral disease.

This study identifies key glycoprotein residues that enhance the efficacy of a CCHFV vaccine by modulating cleavage and fusogenicity in animal models.

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

The paper determines high-resolution structures of hantavirus glycoprotein tetramers and related complexes, revealing new insights into their organization and function, and evaluates their potential for vaccine design.

This paper identifies an adaptive mutation in the WIV1-CoV spike protein that enhances ACE2 binding and cell entry by altering spike dynamics, suggesting alternative spillover mechanisms for bat sarbecoviruses.

This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.

The paper investigates how SARS-like bat coronaviruses evolve enhanced receptor binding and cell entry through specific genetic substitutions.

The paper identifies non-neutralizing antibodies from CCHFV survivors that target multiple regions on GP38, showing protective efficacy in rodent models.