John Hunter Thomas

The paper models glymphatic flow as a network of hydraulic resistances under different parametric scenarios to identify key parameters influencing CSF dynamics.

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.