Humberto Mestre

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

This study examines how AQP4 deletion affects glymphatic function using diffusion MRI techniques, finding altered brain fluid dynamics and reduced glymphatic influx in AQP4 KO mice.

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

Hydraulic resistance of perivascular spaces in the brain

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

Aquaporin-4 dependent glymphatic solute transport in rodent brain

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.