Philipp Khaitovich

This study compares chromatin architecture in iPSC-derived neurons to fetal and mature neurons, finding iPSC-derived neurons resemble fetal neurons and have distinct chromatin features.

This study identifies accelerated aging patterns in 3D genome organization and transcriptome in schizophrenia using Hi-C data and transcriptomic analysis.

The paper investigates how Polycomb proteins regulate gene expression in human cortical neurons through long-range chromatin interactions, showing their role in cell-type specification.

The paper maps lipidomic and transcriptomic profiles in human brain regions, revealing distinct spatial patterns and three classes of lipid-gene relationships.

The paper analyzes lipidome changes in white matter of schizophrenia patients and identifies alterations in myelin-forming and mitochondrial lipid classes.

The paper maps 3D genome architecture in neuronal and non-neuronal cells, finding reduced compartmentalization and increased long-range polycomb interactions in neurons.

The paper analyzes gene expression in multiple tissues across development and ageing in mice, finding that tissues converge in expression patterns with age, associated with loss of tissue identity.

This study uses single-cell genomics to compare brain development in humans, chimpanzees, and macaques, identifying human-specific gene regulatory features.

The paper identifies a class of microRNA targets involving bulge structures and shows they can be recognized by miRNAs, improving computational target prediction when combined with conservation.

This study estimates the timing of natural selection in the human genome over the past half-million years, identifying selection events related to brain evolution and Alzheimer's disease pathways.

The paper evaluates gene expression variation in the human placenta, finding 33.2% within-individual, 58.9% among-individual, and 7.8% among-human-group variation, with selection pressures influencing most genes.

The paper analyzes testis transcriptomes across primates to show convergent evolution linked to mating strategies, finding both tissue composition shifts and cell-autonomous changes.