Megan T. Baldridge

The paper develops dsRADAR, a method using ADAR3-derived dsRNA-binding domains to detect and quantify dsRNA with higher sensitivity and specificity than existing antibodies.

This study shows that STAT1 in myeloid cells prevents MNV-induced hepatitis and fibrosis by controlling viral spread and myeloid cell activation.

This study shows that gut microbe-derived short-chain fatty acids reduce joint inflammation after alphavirus infection by modulating immune cell activity.

This study identifies Trim47 as a host restriction factor that inhibits murine norovirus strain CR6 but not strain CW3, revealing strain-specific antiviral mechanisms.

This study shows microbiota-derived indole metabolites inhibit rotavirus infection in human infants and animal models through the AhR pathway.

This study shows that early-life Cryptosporidium parvum infection in mice disrupts oral tolerance by altering regulatory T cell development and inducing TH1 immune responses to dietary antigens.

This study characterizes the microbiome assembly in neonatal mice from birth to adulthood, showing that microbial diversity increases after day 14 and is largely complete by day 21.

The paper shows ATG-3 limits Orsay virus infection in C. elegans by regulating collagen pathways, independent of autophagic flux.

This study identifies SLC35A2 as a host factor essential for paramyxovirus fusion during infection, showing its role in virus-cell and cell-to-cell fusion events.

This study compares bacterial and viral transfer methods in mouse microbiota transplantation, finding co-housing more effective than fecal or cecal transplantation for rapid reconstitution.

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.