Teodora Goranova

The paper generates and characterizes three new HGSOC cell lines that retain genomic and pathologic features of their parental tumors, providing models for studying chemoresistance.

FrenchFISH improves DNA copy number quantification from FISH images by using Poisson models, outperforming manual and automated methods in ovarian cancer tissue sections.

The paper shows that selecting short DNA fragments in plasma improves the detection of circulating tumour DNA by enriching mutated DNA, enabling identification of copy number alterations previously undetected.