Cancer BiologyScience AdvancesPeer-reviewed
TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition
Jean-François Spinella, Jalila Chagraoui, Isabel Boivin…·Guy Sauvageau
2 citationstop 2%
Author
Institute for Research in Immunology and CancerORCID 0000-0002-7174-0554Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Jean-François Spinella, Jalila Chagraoui, Isabel Boivin…·Guy Sauvageau
Bernhard Lehnertz, Maéva Langouët, Sophie Corneau…·Guy Sauvageau
This study edits the CD33 epitope in cord blood HSPCs to reduce toxicity from CD33-targeted therapies while maintaining anti-leukemic efficacy.
Bernhard Lehnertz, Jalila Chagraoui, Tara MacRae…·Guy Sauvageau
This study identifies HLF as a specific marker for human hematopoietic stem cells and develops a genomic reporter system to track its expression.