Jean-François Spinella

This study edits the CD33 epitope in cord blood HSPCs to reduce toxicity from CD33-targeted therapies while maintaining anti-leukemic efficacy.

EPCY ranks genes by predictive power using cross-validated classifiers and density estimation, outperforming DEG-based methods in selecting robust candidate genes.

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.