Developmentally-orchestrated mitochondrial processes prime the selective inheritance against harmful mitochondrial DNA mutations
Zhe Chen, Zongheng Wang, Guofeng Zhang, Christopher K. E. Bleck, Dillon J. Chung, Grey P. Madison, Eric Lindberg, Christian A. Combs, Robert S. Balaban, Hong Xu
The paper investigates mtDNA selective inheritance in Drosophila, showing that developmentally-orchestrated mitochondrial processes like fission and transcription enable purifying selection against harmful mutations.
The Journal of Cell Biology · Apr 11, 2020Peer-reviewedGenetics