Zhe Chen

This paper identifies new drug targets in Schistosoma mansoni using a genome-scale pipeline and discovers a p97 allosteric binding site that could lead to species-selective inhibitors.

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

The paper develops a modular exosome-based platform for targeted CRISPR/Cas9 genome editing, demonstrating efficient delivery and gene editing in vitro and in vivo.

The paper investigates mtDNA selective inheritance in Drosophila, showing that developmentally-orchestrated mitochondrial processes like fission and transcription enable purifying selection against harmful mutations.