Gábor Zoltán Boross

The paper identifies HBO1 and MLL1 complexes as key tumor suppressors in lung cancer using in vivo functional screens of epigenetic regulators.

The paper uses in vivo genome editing to study genetic interactions in lung cancer, finding widespread negative epistasis among tumor suppressor genes.

This study identifies principles of metabolome conservation across species by analyzing multispecies datasets and shows that abundance, essentiality, and disease association predict conservation patterns.