Author

Jess D. Hebert

Stanford MedicineORCID 0000-0002-8778-5941Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

Dmitri A. PetroviD· 5 shared Laura AndrejkaiD· 5 shared Monte M. WinslowiD· 5 shared Yuning J. TangiD· 5 shared Colin R. DetrickiD· 3 shared Haiqing XuiD· 3 shared Paloma A. RuiziD· 3 shared Saswati KarmakariD· 3 shared

Activity by Year

2024-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

Dmitri A. PetrovORCID

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5 papers

Recent·Most cited

Aging represses lung tumorigenesis and alters tumor suppression

Emily G. Shuldiner, Saswati Karmakar, Min K. Tsai, Jess D. Hebert, Yuning J. Tang, Laura Andrejka, Maggie R. Robertson, Minwei Wang, Colin R. Detrick, Hongchen Cai, Rui Tang, Christian A. Kunder, David M. Feldser, Dmitri A. Petrov, Monte M. Winslow

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

Nature Aging · Nov 4, 2025Peer-reviewedCancer Biology

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

Yuning J. Tang, Haiqing Xu, Nicholas W. Hughes, Paloma A. Ruiz, Samuel H. Kim, Emily G. Shuldiner, Steven S. Lopez, Jess D. Hebert, Saswati Karmakar, Laura Andrejka, Deniz Nesli Dolcen, Gábor Zoltán Boross, Pauline Chu, Christian A. Kunder, Colin R. Detrick, , Monte M. Winslow

The paper identifies HBO1 and MLL1 complexes as key tumor suppressors in lung cancer using in vivo functional screens of epigenetic regulators.

Cancer Discovery · Sep 25, 2025Peer-reviewedCancer Biology

Efficient and multiplexed somatic genome editing with Cas12a mice

Jess D. Hebert, Haiqing Xu, Yuning J. Tang, Paloma A. Ruiz, Colin R. Detrick, Jing Wang, Nicholas W. Hughes, Oscar Donosa, Vicky P. Siah, Laura Andrejka, Saswati Karmakar, Irenosen Aboiralor, Rui Tang, Rocío Sotillo, Julien Sage, , Monte M. Winslow

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Nature Biomedical Engineering · May 30, 2025Peer-reviewedCancer Biology

Combinatorial in vivo genome editing identifies widespread epistasis during lung tumorigenesis

Jess D. Hebert, Yuning J. Tang, Márton Szamecz, Laura Andrejka, Steven S. Lopez, Dmitri A. Petrov, Gábor Zoltán Boross, Monte M. Winslow

The paper uses in vivo genome editing to study genetic interactions in lung cancer, finding widespread negative epistasis among tumor suppressor genes.

Molecular Biology and Evolution · Feb 1, 2025Peer-reviewedCancer Biology

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis

Emily L. Ashkin, Yuning J. Tang, Haiqing Xu, King L. Hung, Julia A. Belk, Hongchen Cai, Steven S. Lopez, Deniz Nesli Dolcen, Jess D. Hebert, Rui Li, Paloma A. Ruiz, Tula Keal, Laura Andrejka, Howard Y. Chang, Dmitri A. Petrov, , Monte M. Winslow

This study identifies a STAG2-PAXIP1/PAGR1 tumor-suppressive axis in lung cancer by showing their combined role in suppressing oncogenic KRAS-driven tumorigenesis.

The Journal of Experimental Medicine · Oct 31, 2024Peer-reviewedCancer Biology